Beilstein J. Org. Chem.2017,13, 111–119, doi:10.3762/bjoc.13.14
for inlinereactionanalysis due to its rapid data generation, however, it can often be difficult to interpret for complex multifunctional systems. On the other hand, chromatographic analysis methods produce much more concise spectra allowing quantitative data to be extrapolated, however, they often
reactionanalysis; reaction optimisation; selective laser melting; stereolithography; Introduction
Additive manufacturing (AM), or as it is widely known ‘3D printing’, is the internationally recognised term used to describe a wide range of manufacturing processes that can generate complex three
equipment, allowing automated online and inline optimisation of the reaction medium. This set-up allowed the optimisation of two reactions, a ketone functional group interconversion and a fused polycyclic heterocycle formation, via spectroscopic and chromatographic analysis.
Keywords: 3D printing; inline
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Graphical Abstract
Scheme 1:
The reaction of (R)-(−)-carvone (1) with semicarbazide to form the corresponding semicarbazone 2.